The Product Life Cycle was introduced in Marketing Management class. Recall or review the Product Life
Cycle (see the Product Life Cycle video in this Module), then write a 2 â 3 page paper that examines how
design can be used in relation to the creation and marketing of a product in each of the four phases of the
Product Life Cycle
Sample Solution
Parasite density with residual SDX: Parasitemia was compared between patients had residual SDX in (n=49) on day 0; 1154 to 80238 asexual parasites/âl (mean âSD: 16733â18077asexual parasites/âl, P<0.05**) and those with no SDX on day 0 (n=240), that is, 616 to 99290 asexual parasites/âl (meanâ SD: 25023â26665asexual parasites/âl, P<0.05**). Low level of residual SDX in those samples which had higher parasite density per microliter of blood and vice versa Molecular markers of drug resistance Pfdhfr: To monitor the PYR drug resistance in collected 295 samples, out of these samples, 288 samples could be amplified for dhfr and dhps both gene. In dhfr gene, double mutation was observed highest frequency (71.9%) followed by single (9%) and triples (2.4%) mutation and 16.7% samples had wild type genotype. Frequency of double mutation (59+108) was higher in Madhya Pradesh (97.5%) followed by Chhattisgarh (75.4%), Jharkhand (64.8%) and Odisha (46.5%) of the samples. Single mutation was seen 18.3%, 12.7%, 3% and 2.5% in Odisha, Jharkhand, Chhattisgarh and Madhya Pradesh samples, respectively. Triple mutation was observed in 9.1% isolate in Chhattisgarh and only 1.4% isolates from Jharkhand. While wild genotype was observed in highest frequency (35.2%) in Odisha followed by Jharkhand (21.1%) and Chhattisgarh isolates (12.1%). Pfdhps:- To monitor the SDX drug resistance pattern in amplified of 288 samples, wild type dhps genotype was prevalent with highest frequency (51%) followed by dhps triple (26%), double (11.8%), & single (11.1%) mutation.>
Parasite density with residual SDX: Parasitemia was compared between patients had residual SDX in (n=49) on day 0; 1154 to 80238 asexual parasites/âl (mean âSD: 16733â18077asexual parasites/âl, P<0.05**) and those with no SDX on day 0 (n=240), that is, 616 to 99290 asexual parasites/âl (meanâ SD: 25023â26665asexual parasites/âl, P<0.05**). Low level of residual SDX in those samples which had higher parasite density per microliter of blood and vice versa Molecular markers of drug resistance Pfdhfr: To monitor the PYR drug resistance in collected 295 samples, out of these samples, 288 samples could be amplified for dhfr and dhps both gene. In dhfr gene, double mutation was observed highest frequency (71.9%) followed by single (9%) and triples (2.4%) mutation and 16.7% samples had wild type genotype. Frequency of double mutation (59+108) was higher in Madhya Pradesh (97.5%) followed by Chhattisgarh (75.4%), Jharkhand (64.8%) and Odisha (46.5%) of the samples. Single mutation was seen 18.3%, 12.7%, 3% and 2.5% in Odisha, Jharkhand, Chhattisgarh and Madhya Pradesh samples, respectively. Triple mutation was observed in 9.1% isolate in Chhattisgarh and only 1.4% isolates from Jharkhand. While wild genotype was observed in highest frequency (35.2%) in Odisha followed by Jharkhand (21.1%) and Chhattisgarh isolates (12.1%). Pfdhps:- To monitor the SDX drug resistance pattern in amplified of 288 samples, wild type dhps genotype was prevalent with highest frequency (51%) followed by dhps triple (26%), double (11.8%), & single (11.1%) mutation.>
